Sortilin: Proteins and Enzymes
Sortilin is a type I transmembrane glycoprotein that is one of five known members of the mammalian vacuolar protein sorting 10p domain (Vps10p-D) family of sorting receptors. During murine development, sortilin is mainly expressed in the nervous system where it is a receptor for neuropeptides including neurotensin, NGF, and BDNF. Pro-NGF (or the NGF propeptide alone) binds Sortilin with much higher affinity than does mature NGF. Pro-NGF binding to the receptor complex of Sortilin and the NGF Receptor/p75NTR may result in the induction of apoptosis.
3 results for "Sortilin Proteins and Enzymes" in Products
3 results for "Sortilin Proteins and Enzymes" in Products
Sortilin: Proteins and Enzymes
Sortilin is a type I transmembrane glycoprotein that is one of five known members of the mammalian vacuolar protein sorting 10p domain (Vps10p-D) family of sorting receptors. During murine development, sortilin is mainly expressed in the nervous system where it is a receptor for neuropeptides including neurotensin, NGF, and BDNF. Pro-NGF (or the NGF propeptide alone) binds Sortilin with much higher affinity than does mature NGF. Pro-NGF binding to the receptor complex of Sortilin and the NGF Receptor/p75NTR may result in the induction of apoptosis.
| Source: | NS0 |
| Accession #: | Q99523 |
| Applications: | Bind |
| Source: | NS0 |
| Accession #: | Q6PHU5 |
| Applications: | Bind |
| Applications: | AC |