TGF-beta 2: cDNA Clones

TGF- beta 2 (transforming growth factor beta 2) is a highly pleiotropic cytokine with important functions during cardiac, lung, craniofacial, limb, eye, ear, and urogenital system development. It forms a latent complex with LAP and one of the LTBP TGF-beta binding proteins. The active protein is released by Plasmin, MMP, Thrombospondin 1, or Integrin action. TGF-beta 2 signals through TGF-beta RII, Betaglycan, and either TGF-beta RI/ALK-5 or ALK-1.