Vanilloid R1/TRPV1: Proteins and Enzymes

Vanilloid Receptor 1 (VR1) also known as TRPV1 (Transient Receptor Potential Vanilloid 1) and capsaicin receptor, is a 115 kDa integral membrane ion channel that has six transmembrane domains and contains intracellular N-and C-termini. Vanilloid Receptor 1 contributes to normal pain and temperature sensation and also has a sensory-effector function. By alternative splicing, at least three VR1 isoforms are known. The sequence of residues 4 - 21 of rat VR1 is 78% and 28% identical to that of mouse and human VR1, respectively.