VDR-like Receptor Agonists: Small Molecules and Peptides
Vitamin D Receptor (VDR; NR1I1) is a member of the steroid receptor family related to the PXR and CARs. The natural ligand of VDR is 1, 25 di-hydroxyvitamin D3. VDR is expressed in osteoblasts, osteocytes, osteoclasts, bone, bone marrow, thymus and small intestine. VDR plays critical roles in calcium homeostasis, bone development and mineralization, as well as control of cell growth and differentiation. RXRs are the major partners for VDR since by heterodimerizing with VDR, they increase their DNA-binding affinity and select the correct spacing of direct repeat elements.
2 results for "VDR-like Receptor Agonists Small Molecules and Peptides" in Products
2 results for "VDR-like Receptor Agonists Small Molecules and Peptides" in Products
VDR-like Receptor Agonists: Small Molecules and Peptides
Vitamin D Receptor (VDR; NR1I1) is a member of the steroid receptor family related to the PXR and CARs. The natural ligand of VDR is 1, 25 di-hydroxyvitamin D3. VDR is expressed in osteoblasts, osteocytes, osteoclasts, bone, bone marrow, thymus and small intestine. VDR plays critical roles in calcium homeostasis, bone development and mineralization, as well as control of cell growth and differentiation. RXRs are the major partners for VDR since by heterodimerizing with VDR, they increase their DNA-binding affinity and select the correct spacing of direct repeat elements.
Vitamin D receptor (VDR) agonist
| Alternate Names: | 1,25-Dihydroxyvitamin D3 |
| Chemical Name: | (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol |
| Purity: | ≥99% (HPLC) |
Selective CAR agonist
| Chemical Name: | 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime |
| Purity: | ≥98% (HPLC) |
