Alkaline Phosphatase/ALPP Antibody (ALPP/516) [FITC]

Validated:

FITC (Excitation = 495 nm, Emission = 519 nm)

Monoclonal Mouse IgG₁ kappa Clone # ALPP/516

Please see the vial label for concentration. If unlisted please contact technical services.

Recombinant full-length human Alkaline Phosphatase/ALPP protein (Uniprot: P05187)

Cytoplasmic and cell surface

PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo-glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APs in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This monoclonal antibody binds equally well to all common allelic variants (S, F, FS and I) of PLAP and to some variants of AP from normal human testis. This monoclonal antibody can be used as tracer antibody in ELISA to detect PLAP in serum of S, F, FS and I phenotypes.

Germ Cell Tumor Marker

Monoclonal

Mouse

IgG₁ kappa

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Protein A or G purified

PBS

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.