alpha-L-Iduronidase/IDUA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49126

Novus Biologicals, part of Bio-Techne
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NBP2-49126
NBP2-49126-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all alpha-L-Iduronidase/IDUA Antibodies »

Product Summary for alpha-L-Iduronidase/IDUA Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: LTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for alpha-L-Iduronidase/IDUA Antibody

Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126]

Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126]

Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126] - Staining of human skeletal muscle shows low positivity as expected.
Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126]

Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126]

Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126] - Analysis in human stomach and skeletal muscle tissues. Corresponding IDUA RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126]

Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126]

Immunohistochemistry-Paraffin: alpha-L-Iduronidase/IDUA Antibody [NBP2-49126] - Staining of human prostate shows strong positivity in cytoplasm granular in glandular cells.
View 2 more images

Applications for alpha-L-Iduronidase/IDUA Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: alpha-L-Iduronidase/IDUA

alpha-L-Iduronidase, encoded by the IDUA gene, is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non-reducing terminal a-L-iduronic acid residues in GAGs, including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I causes progressive cellular, tissue, and organ damage.

Alternate Names

alphaLIduronidase, IDA, IDUA

Gene Symbol

IDUA

Additional alpha-L-Iduronidase/IDUA Products

Product Documents for alpha-L-Iduronidase/IDUA Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for alpha-L-Iduronidase/IDUA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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