Bcl-10 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76882

Novus Biologicals, part of Bio-Techne
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NBP1-76882
NBP1-76882-0.025mg
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Bcl-10 Antibodies »

Product Summary for Bcl-10 Antibody - BSA Free

Immunogen

Antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10. The immunogen is located within the first 50 amino acids of Bcl-10. Amino Acid Squence: APSLTEEDLTEVKKDC

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

31 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Bcl-10 Antibody - BSA Free

Western Blot: Bcl-10 AntibodyBSA Free [NBP1-76882]

Western Blot: Bcl-10 AntibodyBSA Free [NBP1-76882]

Western Blot: Bcl-10 Antibody [NBP1-76882] - Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution.
Immunocytochemistry/ Immunofluorescence: Bcl-10 Antibody - BSA Free [NBP1-76882]

Immunocytochemistry/ Immunofluorescence: Bcl-10 Antibody - BSA Free [NBP1-76882]

Immunocytochemistry/Immunofluorescence: Bcl-10 Antibody [NBP1-76882] - Immunofluorescence of Bcl-10 in Raji cells with Bcl-10 antibody at 10 ug/mL.
Immunocytochemistry/ Immunofluorescence: Bcl-10 Antibody - BSA Free [NBP1-76882]

Immunocytochemistry/ Immunofluorescence: Bcl-10 Antibody - BSA Free [NBP1-76882]

Immunocytochemistry/Immunofluorescence: Bcl-10 Antibody [NBP1-76882] - Raji cells with Bcl10 antibody at 1 ug/mL.

Applications for Bcl-10 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

1-10 ug/ml

Western Blot

0.5 ug/ml
Application Notes
An approximately 31 kDa band can be detected in Western Blot.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Bcl-10

Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kappaB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation . Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.

Long Name

B Cell Lymphoma/Leukemia 10

Alternate Names

Bcl10, c-E10, CARMEN, CIPER, CLAP, mE10

Gene Symbol

BCL10

UniProt

AF134395 (Human)

Additional Bcl-10 Products

Product Documents for Bcl-10 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Bcl-10 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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