Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

Long Name

B Cell Lymphoma/Leukemia w

Alternate Names

BCL2L2, Bclw

Gene Symbol

BCL2L2

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Product Documents for BCL-W/BCL2L2 Antibody (PCRP-BCL2L2-1A4) [Janelia Fluor® 635]

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Product Specific Notices for BCL-W/BCL2L2 Antibody (PCRP-BCL2L2-1A4) [Janelia Fluor® 635]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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BCL-W/BCL2L2 Antibody (PCRP-BCL2L2-1A4) [Janelia Fluor® 635]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14166JF635

Key Product Details

Species Reactivity

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Product Summary for BCL-W/BCL2L2 Antibody (PCRP-BCL2L2-1A4) [Janelia Fluor® 635]

Immunogen

Localization

Clonality

Host

Isotype

Applications for BCL-W/BCL2L2 Antibody (PCRP-BCL2L2-1A4) [Janelia Fluor® 635]

Flow Cytometry

Immunocytochemistry/ Immunofluorescence

Immunoprecipitation

Protein Array

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

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Stability & Storage

Background: Bcl-w