CDR2 Antibody [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-58345F

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Bovine, Primate

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CDR2 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to a C-terminal region of human CDR2 [Swiss-Prot# Q01850]

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: rat (85%).

Localization

Cytoplasmic and Nuclear

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for CDR2 Antibody [FITC]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: CDR2

CDR2 (cerebellar degeneration-related protein 2; encoded by gene CDR2 or PCD17) was initially discovered in a search for novel PHD1-interacting proteins, and comprehensive analysis of human cancers revealed very strong CDR2 expression in papillary subtype of renal cell carcinoma, wherein high CDR2 protein levels correlated with strongly attenuated expression of HIF target genes. Accordingly, CDR2 overexpression in cancer cell lines reduced HIF-dependent transcriptional regulation, possibly because of both regulation of PHD1 protein expression and suppression of transactivation potential of HIF-1alpha. CDR2 through its leucine zipper motif has been shown to interact with CMYC, cell cycle-related proteins and with protein kinases suggesting its important role in biological functions including signal transduction, gene transcription and cellular proliferation.

Alternate Names

CDR62, cerebellar degeneration-related protein (62kD), cerebellar degeneration-related protein 2, cerebellar degeneration-related protein 2, 62kDa, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen, PCD17, Yo, Yo paraneoplastic antigen

Gene Symbol

CDR2

Additional CDR2 Products

Product Documents for CDR2 Antibody [FITC]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CDR2 Antibody [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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