Chitinase 3-like 1/YKL-40 Antibody (CL12241)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21212

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # CL12241

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Chitinase 3-like 1/YKL-40 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a Synthetic Peptide of P36222. Actual immunogen sequence is proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Chitinase 3-like 1/YKL-40 Antibody (CL12241)

Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -

Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -

Staining of human liver shows moderate granular cytoplasmic positivity in hepatocytes.
Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -

Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -

Staining of human cerebral cortex shows moderate granular cytoplasmic positivity in glial cells.
Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -

Immunohistochemistry-Paraffin: Chitinase 3-like 1 Antibody [NBP3-21212] -

Staining of human astrocytoma shows strong cytoplasmic positivity in tumor cells.
View 4 more images

Applications for Chitinase 3-like 1/YKL-40 Antibody (CL12241)

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Chitinase 3-like 1/YKL-40

Chitinase 3-like 1 (CHI3L1), also called BRP39 in mouse or YKL-40 in humans, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.

Alternate Names

CHI3L1, Chitinase 3 like 1, HCgp39, YKL-40

Gene Symbol

CHI3L1

Additional Chitinase 3-like 1/YKL-40 Products

Product Documents for Chitinase 3-like 1/YKL-40 Antibody (CL12241)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Chitinase 3-like 1/YKL-40 Antibody (CL12241)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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