Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # PC 7

Format

BSA Free

Concentration

1.0 mg/ml

View all Coagulation Factor XIV/Protein C Antibodies »

Product Summary for Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free

Immunogen

Recombinant human activated protein C

Epitope

Specific for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with alpha1-antitrypsin.

Specificity

Has specificity for a conformation dependent neoepitope that is expressed in activated protein C upon complex-formation with alpha1-antitrypsin. No reaction is seen to non-complexed alpha1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free

ELISA: Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free [NBP1-05113]

ELISA: Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free [NBP1-05113]

ELISA: Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free [NBP1-05113] - Human fallopian tube stained with Coagulation Factor XIV/Protein C Antibody.

Applications for Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free

Application
Recommended Usage

ELISA

1:500
Application Notes
ELISA: NBP1-05113 reacts strongly with APC-AAT complexes in ELISA. It can be used in sandwich ELISA in combination with a polyclonal anti-protein C antiserum. Note, that the conformational neoepitope expressed in the APC-AAT complex can also be expressed in APC coated directly onto a high-binding microtiter plate.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM Phosphate (pH 7.4) and 0.5M NaCl

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Coagulation Factor XIV/Protein C

Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is approximately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is approximately 3 ug/ml. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, og which alpha1-antitrypsin (AAT) and protein C inhibitor (PCI) are the most important.

Long Name

Vitamin K-dependent Protein C

Alternate Names

Autoprothrombin IIA, PROC, Protein C

Gene Symbol

PROC

Additional Coagulation Factor XIV/Protein C Products

Product Documents for Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Coagulation Factor XIV/Protein C Antibody (PC 7) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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