Common beta Chain Antibody (7B6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26643

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # 7B6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Common beta Chain Antibodies »

Product Specifications

Immunogen

Recombinant Human Common beta Chain protein [UniProt P32927]

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Scientific Data Images for Common beta Chain Antibody (7B6)

Common beta Chain Antibody (7B6)

ELISA: Common beta Chain Antibody (7B6) [NBP3-26643] -

ELISA: Common beta Chain Antibody (7B6) [NBP3-26643] - The Binding Activity of Common beta Chain with Common beta Chain Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human Common beta Chain at 2 ug/mL can bind Common beta Chain Antibody, the EC50 is 0.1594-0.3046 ng/mL.

Applications for Common beta Chain Antibody (7B6)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50% Glycerol, 0.01M PBS, PH 7.4

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: Common beta Chain

Interleukin-3 receptor (IL-3R) is a heterodimer cytokine composed of alpha chain and beta chain. IL-3R beta subunit (CD131, beta C) is a common shared beta chain of the receptor for granulocyte- macrophage colony-stimulating factor (GM-CSF) and IL-5 (1). While the beta chain can not bind to the ligand alone, but it is essential for high affinity ligand binding (2). The cytoplasmic portion of the beta chain contains the major domains necessary for ligand-induced proliferation (3). IL-3R beta is expressed in neutrophil, eosinophil, monocyte, and hematpoietic stem cells. A point mutation leading to defective IL-3R beta expression has been associated to Human pulmonary alveolar proteinosis (PAP), a rare cause of respiratory failure (4).

Alternate Names

CD131, CSF2RB, GM-CSF R beta, IL-3 R beta, IL-5 R beta

Gene Symbol

CSF2RB

Additional Common beta Chain Products

Product Documents for Common beta Chain Antibody (7B6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Common beta Chain Antibody (7B6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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