Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Chicken (100%), Equine (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence

Label

Biotin

Antibody Source

Monoclonal Mouse IgG Clone # 10D774

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all D4-GDI/RhoGDI2 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to human D4-GDI/RhoGDI2 was used as the immunogen.

Reactivity Notes

Cross reacts with Human.

Specificity

A 28 kDa band is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Applications for D4-GDI/RhoGDI2 Antibody (10D774) [Biotin]

Application
Recommended Usage

ELISA

1-2 ug/ml
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: D4-GDI/RhoGDI2

D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.

Alternate Names

ARHGDIB Rho GDP dissociation inhibitor (GDI) beta, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2

Gene Symbol

ARHGDIB

Additional D4-GDI/RhoGDI2 Products

Product Documents for D4-GDI/RhoGDI2 Antibody (10D774) [Biotin]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for D4-GDI/RhoGDI2 Antibody (10D774) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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