Dkk-4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-98330

Novus Biologicals, part of Bio-Techne
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NBP1-98330
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Key Product Details

Species Reactivity

Validated:

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

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Product Summary for Dkk-4 Antibody

Immunogen

The immunogen for this antibody is Dkk4 - C-terminal region. Peptide sequence RTSDCGPGLCCARHFWTKICKPVLREGQVCSRRGHKDTAQAPEIFQRCDC. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Dkk-4 Antibody

Western Blot: Dkk-4 Antibody [NBP1-98330]

Western Blot: Dkk-4 Antibody [NBP1-98330]

Western Blot: Dkk-4 Antibody [NBP1-98330] - Antibody Dilution: 1.0ug/ml Sample Tissue: Mouse Pancreas.

Applications for Dkk-4 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dkk-4

Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Long Name

Dickkopf-4

Alternate Names

Dkk4

Gene Symbol

DKK4

UniProt

NP_663567 (Mouse)

Additional Dkk-4 Products

Product Documents for Dkk-4 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Dkk-4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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