DNA-PKcs [p Ser2056] Antibody (SR1789)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21517

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21517-100ul
NBP3-21517-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1789

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DNA-PKcs Antibodies »

Product Summary for DNA-PKcs [p Ser2056] Antibody (SR1789)

Immunogen

A synthesized peptide derived from human phospho-DNA-PKcs [Ser2056] (Uniprot #: P78527)

Modification

p Ser 2056

Specificity

Detects endogenous levels of total phospho-DNA PKcs [Ser2056]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

469 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DNA-PKcs [p Ser2056] Antibody (SR1789)

Western Blot: DNA-PKcs [p Ser 2056] Antibody (SR1789) [NBP3-21517] -

Western Blot: DNA-PKcs [p Ser 2056] Antibody (SR1789) [NBP3-21517] - Western blot analysis using NBP3-21517 in alkaline treated Jurkat cell lysate.

Immunohistochemistry: DNA-PKcs [p Ser 2056] Antibody (SR1789) [NBP3-21517] -

Immunohistochemistry: DNA-PKcs [p Ser 2056] Antibody (SR1789) [NBP3-21517] - Immunohistochemical analysis of paraffin-embedded human colon, using NBP3-21517.

Applications for DNA-PKcs [p Ser2056] Antibody (SR1789)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DNA-PKcs

The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.(supplied by OMIM)

Long Name

DNA-dependent Protein Kinase Catalytic Subunit

Alternate Names

DNAPK, DNAPKcs, DNPK1, HYRC1, p350, PRKDC, XRCC7

Gene Symbol

PRKDC

Additional DNA-PKcs Products

Product Documents for DNA-PKcs [p Ser2056] Antibody (SR1789)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for DNA-PKcs [p Ser2056] Antibody (SR1789)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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