Endoglin/CD105 Antibody (CL1912) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-34493

Novus Biologicals, part of Bio-Techne
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NBP2-34493
NBP2-34493-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL1912

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Endoglin/CD105 Antibodies »

Product Specifications

Immunogen

This antibody was developed using a recombinant protein derived from P17813, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Endoglin/CD105 Antibody (CL1912) - BSA Free

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493] - Staining of smooth muscle shows absence of positivity in myocytes (negative control).
Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493] - Staining of human renal cancer shows strong immunoreactivity in the blood vessels.
Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (CL1912) [NBP2-34493] - Staining of human liver cancer shows positivity in the sinusoids.
View 3 more images

Applications for Endoglin/CD105 Antibody (CL1912) - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Endoglin/CD105

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF- szlig1, TGF- szlig3 and modulates TGF- szlig signaling by interacting with TGF- szlig receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.

Alternate Names

CD105, ENG

Gene Symbol

ENG

UniProt

P17813

Additional Endoglin/CD105 Products

Product Documents for Endoglin/CD105 Antibody (CL1912) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Endoglin/CD105 Antibody (CL1912) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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