Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-43882

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL1912

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all Endoglin/CD105 Antibodies »

Product Specifications

Immunogen

This antibody was generated using a recombinant protein sequence of P17813, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free

Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody [NBP3-43882]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody [NBP3-43882]

Staining of human colon shows moderate positivity in the endothelium of blood vessels.
Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody [NBP3-43882]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody [NBP3-43882]

Staining of human cerebral cortex shows strong immunoreactivity in the blood vessels.
Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody [NBP3-43882]

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody [NBP3-43882]

Staining of human liver cancer shows positivity in the sinusoids.
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Applications for Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS with Trehalose

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Endoglin/CD105

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF- szlig1, TGF- szlig3 and modulates TGF- szlig signaling by interacting with TGF- szlig receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.

Alternate Names

CD105, ENG

Gene Symbol

ENG

Additional Endoglin/CD105 Products

Product Documents for Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Endoglin/CD105 Antibody (CL1912) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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