Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Long Name

Forkhead Box P3

Alternate Names

AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Gene Symbol

FOXP3

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Product Documents for FoxP3 Antibody (FOXP3/7990R) [Janelia Fluor® 635]

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Product Specific Notices for FoxP3 Antibody (FOXP3/7990R) [Janelia Fluor® 635]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FoxP3 Antibody (FOXP3/7990R) [Janelia Fluor® 635]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20941JF635

Key Product Details

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Product Summary for FoxP3 Antibody (FOXP3/7990R) [Janelia Fluor® 635]

Immunogen

Localization

Clonality

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Applications for FoxP3 Antibody (FOXP3/7990R) [Janelia Fluor® 635]

Immunohistochemistry-Paraffin

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Background: FoxP3