FXR and LXR fall into a category of proteins termed orphan receptors; because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR.

Long Name

Farnesoid X-activated receptor

Alternate Names

BAR, HRR-1, NR1H4, RIP14

Gene Symbol

NR1H4

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Product Specific Notices for FXR/NR1H4 Antibody [Janelia Fluor® 669]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FXR/NR1H4 Antibody [Janelia Fluor® 669]

Novus Biologicals, part of Bio-Techne | Catalog # NB400-153JF669

Key Product Details

Species Reactivity

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Product Specifications

Immunogen

Reactivity Notes

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Applications for FXR/NR1H4 Antibody [Janelia Fluor® 669]

Immunocytochemistry/ Immunofluorescence

Western Blot

Formulation, Preparation, and Storage

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Background: FXR/NR1H4