FYB/ADAP/SLAP130 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76810

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all FYB/ADAP/SLAP130 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 20 amino acid synthetic peptide from near the carboxy terminus of human ADAP. The immunogen is located within amino acids 640 - 690 of ADAP. Amino Acid Squence: LKGKDDRKKSIREKPKVSD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FYB/ADAP/SLAP130 Antibody - BSA Free

Western Blot: FYB/ADAP/SLAP130 AntibodyBSA Free [NBP1-76810]

Western Blot: FYB/ADAP/SLAP130 AntibodyBSA Free [NBP1-76810]

Western Blot: FYB/ADAP/SLAP130 Antibody [NBP1-76810] - K562 cell lysate with FYB antibody at (A) 0.5 and (B) 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: FYB/ADAP/SLAP130 Antibody - BSA Free [NBP1-76810]

Immunocytochemistry/ Immunofluorescence: FYB/ADAP/SLAP130 Antibody - BSA Free [NBP1-76810]

Immunocytochemistry/Immunofluorescence: FYB/ADAP/SLAP130 Antibody [NBP1-76810] - K562 cells with FYB antibody at 10 ug/ml.

Applications for FYB/ADAP/SLAP130 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10-20 ug/ml

Western Blot

0.5-1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FYB/ADAP/SLAP130

The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.

Long Name

FYN Binding Protein (FYB-120/130)

Alternate Names

ADAP, PRO0823, SLAP130

Gene Symbol

FYB1

UniProt

NP_001456 (Human)

Additional FYB/ADAP/SLAP130 Products

Product Documents for FYB/ADAP/SLAP130 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for FYB/ADAP/SLAP130 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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