Glypican 3 Antibody (1G12 + GPC3/863) [Allophycocyanin]

Validated:

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Monoclonal Mouse IgG₁ kappa Clone # 1G12 + GPC3/863

Please see the vial label for concentration. If unlisted please contact technical services.

Recombinant fragment containing amino acids 511-580 of human Glypican 3 (1G12); Recombinant full-length human GPC3 protein (GPC3/863) (Uniprot: P51654)

Cytoplasmic

Glypican-3 (GPC3) is an integral membrane protein that is mutated in the Simpson-Golabi-Behmel syndrome (SGBS). SGBS is characterized by pre- and post-natal overgrowth and is a recessive X-linked condition.GPC3 may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma was significantly higher than that of follicular adenoma. In contrast, GPC 3 is not expressed in anaplastic carcinoma.

Hepatocellular Carcinoma Marker

Monoclonal

Mouse

IgG₁ kappa

Protein A or G purified

PBS

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.