Glypican 3 Products
The glypicans (GPC) constitute a family of glycosylphosphatidylinositol (GPI)-anchored, heparan sulfate proteoglycans. Six members of this family have been identified in mammals (GPC1-GPC6). All glypican core proteins contain an N-terminal signal peptide, a large globular cysteine-rich domain (CRD) with 14 invariant cysteine residues, a stalk-like region containing the heparan sulfate attachment sites, and a C-terminal GPI attachment site.
Mutations in Glypican 3 cause a rare disorder in humans, Simpson-Golabi-Behmel Syndrome, which is characterized by pre- and postnatal overgrowth of multiple tissues and organs and an increased risk for developing embryonic tumors. These features are also present in the mouse knock-out of Glypican 3 indicating that Glypican 3 regulates cell survival and inhibits cell proliferation during development. Glypican 3 has been implicated in regulating many different signaling pathways including: IGF, FGF, BMP and Wnt. An endoproteolytic processing of Glypican 3 by proprotein convertases is required for the modulation of Wnt signaling. Direct interaction of Glypican 3 with FGF-basic has been observed and is mediated by the heparan sulfate chains.
411 results for "Glypican 3" in Products
411 results for "Glypican 3" in Products
Glypican 3 Products
The glypicans (GPC) constitute a family of glycosylphosphatidylinositol (GPI)-anchored, heparan sulfate proteoglycans. Six members of this family have been identified in mammals (GPC1-GPC6). All glypican core proteins contain an N-terminal signal peptide, a large globular cysteine-rich domain (CRD) with 14 invariant cysteine residues, a stalk-like region containing the heparan sulfate attachment sites, and a C-terminal GPI attachment site.
Mutations in Glypican 3 cause a rare disorder in humans, Simpson-Golabi-Behmel Syndrome, which is characterized by pre- and postnatal overgrowth of multiple tissues and organs and an increased risk for developing embryonic tumors. These features are also present in the mouse knock-out of Glypican 3 indicating that Glypican 3 regulates cell survival and inhibits cell proliferation during development. Glypican 3 has been implicated in regulating many different signaling pathways including: IGF, FGF, BMP and Wnt. An endoproteolytic processing of Glypican 3 by proprotein convertases is required for the modulation of Wnt signaling. Direct interaction of Glypican 3 with FGF-basic has been observed and is mediated by the heparan sulfate chains.
Sensitivity: | 20.6 pg/mL |
Applications: | ELISA |
Assay Range: | 78.1 - 5,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma) |
Source: | NS0 |
Accession #: | P51654.1 |
Applications: | Bind |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #1G12 |
Applications: | IHC, WB, ICC/IF, Flow |
Assay Range: | 0.312 - 20 ng/mL |
Applications: | ELISA |
Reactivity: | Human, Rat |
Details: | Mouse IgG1 kappa Monoclonal Clone #GPC3/863 |
Applications: | IHC, ICC/IF, Flow |
For use with catalog number DGLY30
Applications: | ELISA, Ctrl |
His-tag
Source: | NS0 |
Accession #: | P51654.1 |
Applications: | BA |
Source: | HEK293 |
Accession #: | XP_005594665.1 |
Applications: | BA |
Applications: | ELISA |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Human IgG1 Monoclonal Clone #Codrituzumab |
Applications: | ELISA, Flow, Func |
Biotinylated
Source: | CHO |
Accession #: | P51654.1 |
Applications: | BA |
Reactivity: | Human, Mouse |
Details: | Mouse IgG1 Monoclonal Clone #9C2 |
Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
Reactivity: | Human |
Details: | Mouse IgG2B Monoclonal Clone #CL12711 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #307801 |
Applications: | Flow |
Reactivity: | Human, Rat |
Details: | Mouse IgG1 kappa Monoclonal Clone #rGPC3/863 |
Applications: | IHC, ICC/IF, Flow, MA |
Source: | HEK293 |
Accession #: | P51654.1 |
Applications: | BA |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #307801 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #307801 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #307801 |
Applications: | Flow |
Source: | NS0 |
Accession #: | AAH36126 |
Applications: | BA |
Recombinant Monoclonal Antibody.
Reactivity: | Human, Rat |
Details: | Rabbit IgG Monoclonal Clone #GPC3/1534R |
Applications: | IHC, ICC/IF, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #1G12 + GPC3/863 |
Applications: | IHC, ICC/IF, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #SPM595 |
Applications: | IHC, ICC/IF, Flow |