GSK-3 alpha Antibody (S07-3A2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15036

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15036-100ul
NBP3-15036-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S07-3A2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GSK-3 alpha Antibodies »

Product Summary for GSK-3 alpha Antibody (S07-3A2)

Immunogen

A synthetic peptide of human GSK-3 alpha (Uniprot#: P49840)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GSK-3 alpha Antibody (S07-3A2)

Western Blot: GSK-3 alpha Antibody (S07-3A2) [NBP3-15036]

Western Blot: GSK-3 alpha Antibody (S07-3A2) [NBP3-15036]

Western Blot: GSK-3 alpha Antibody (S07-3A2) [NBP3-15036] - Western blot detection of GSK-3 alpha in K562, Rat Brain, Hela cell lysates using GSK-3 alpha Rabbit mAb (1:1000 diluted). Predicted band size: 51kDa. Observed band size: 51kDa.

Applications for GSK-3 alpha Antibody (S07-3A2)

Application
Recommended Usage

Western Blot

1/2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GSK-3 alpha

Glycogen synthases kinase 3 alpha (GSK3-alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-alpha activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4).

Long Name

Glycogen Synthase Kinase 3 alpha

Alternate Names

GSK3 alpha, GSK3A

Gene Symbol

GSK3A

Additional GSK-3 alpha Products

Product Documents for GSK-3 alpha Antibody (S07-3A2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GSK-3 alpha Antibody (S07-3A2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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