GSK-3 alpha Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimers disease, bipolar disorder, and cancer.
68 results for "GSK-3 alpha" in Products
68 results for "GSK-3 alpha" in Products
GSK-3 alpha Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimers disease, bipolar disorder, and cancer.
Highly selective GSK-3 inhibitor; acts as Wnt activator
Alternate Names: | CHIR99021,CT99021 |
Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
Purity: | ≥98% (HPLC) |
CHIR 99021 synthesized to cGMP guidelines
Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
Purity: | ≥99% |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ICC |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, CyTOF-ready, ICC, ICFlow |
Assay Range: | 156 - 10,000 pg/mL |
Applications: | ELISA |
Reactivity: | Human, Mouse |
Details: | Mouse IgG2b Monoclonal Clone #833916 |
Applications: | WB, ICC |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, IHC |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF, IP |
Reactivity: | Human |
Details: | Mouse IgG2b Monoclonal Clone #288901 |
Applications: | ICC |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #4I10Q9 |
Applications: | WB, IP, KO |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | ICC/IF |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #9D5G1 |
Applications: | WB, ELISA, ICC/IF |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, KO |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB |
Applications: | ELISA |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #S07-3A2 |
Applications: | WB |
Reactivity: | Human, Mouse |
Details: | Mouse IgG2a Kappa Monoclonal Clone #SBGSK3a1 |
Applications: | WB |
Reactivity: | Human, Mouse |
Details: | Mouse IgG2a Kappa Monoclonal Clone #SBGSK3a2 |
Applications: | WB |
Applications: | AC |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #4A5 |
Applications: | IHC, ELISA |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #6G12C2 |
Applications: | WB, ELISA |
Applications: | WB |
Applications: | ELISA |
Applications: | ELISA |