GSK-3 beta [p Ser9] Antibody (SR1801)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21576

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP3-21576-100ul
NBP3-21576-50ul
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1801

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GSK-3 beta Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-GSK-3 beta [Ser9] (Uniprot #: P49841)

Modification

p Ser 9

Specificity

Detects endogenous levels of total phospho-GSK-3 beta [Ser9]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GSK-3 beta [p Ser9] Antibody (SR1801)

Immunohistochemistry: GSK-3 beta [p Ser 9] Antibody (SR1801) [NBP3-21576] -

Immunohistochemistry: GSK-3 beta [p Ser 9] Antibody (SR1801) [NBP3-21576] - Immunohistochemical analysis of paraffin-embedded human kidney, using NBP3-21576.

Immunocytochemistry/Immunofluorescence: GSK-3 beta [p Ser 9] Antibody (SR1801) [NBP3-21576] -

Immunocytochemistry/Immunofluorescence: GSK-3 beta [p Ser 9] Antibody (SR1801) [NBP3-21576] - Immunofluorescent analysis of HeLa cells treated with Calyculin A, using NBP3-21576.

Western Blot: GSK-3 beta [p Ser 9] Antibody (SR1801) [NBP3-21576] -

Western Blot: GSK-3 beta [p Ser 9] Antibody (SR1801) [NBP3-21576] - Western blot analysis using NBP3-21576 in 293T cell lysates, treated with Calyculin A.

Applications for GSK-3 beta [p Ser9] Antibody (SR1801)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:5000-1:10000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GSK-3 beta

Glycogen synthase kinase 3beta (GSK-3 beta) is a Serine/Threonine protein kinas involved in the insulin and wingless pathways (1-2). Originally identified as a regulator of glycogen synthase, it has been shown to regulate a diverse array of cellular functions. GSK-3 beta activity is down regulated by phosphorylation on Serine 9 by PKB, or activated by phosphorylation on Tyrosine 216. Once activated, the protein can phosphorylate p53, c-jun, heat shock factor-1 and cyclin D1 (3-4). It is also known to phosphorylate Tau in Allzheimer's disease. Additionally, increased GSK-3 beta protein levels are found in Alzheimer's disease brains.

Long Name

Glycogen Synthase Kinase 3 beta

Alternate Names

GSK3 beta, GSK3B

Gene Symbol

GSK3B

Additional GSK-3 beta Products

Product Documents for GSK-3 beta [p Ser9] Antibody (SR1801)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for GSK-3 beta [p Ser9] Antibody (SR1801)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.