GSK-3 beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
156 results for "GSK-3 beta" in Products
156 results for "GSK-3 beta" in Products
GSK-3 beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
Highly selective GSK-3 inhibitor; acts as Wnt activator
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% (HPLC) |
CHIR 99021 synthesized to cGMP guidelines
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥99% |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG2A Monoclonal Clone #3D10 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
![Western Blot: GSK-3 beta Antibody (3D10)BSA Free [NBP1-47470]](https://resources.bio-techne.com/images/products/GSK-3-beta-Antibody-3D10-Western-Blot-NBP1-47470-img0012.jpg "Western Blot: GSK-3 beta Antibody (3D10)BSA Free [NBP1-47470]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #272536 |
| Applications: | WB, CyTOF-ready, ICC, ICFlow |
| Reactivity: | Human, Mouse, Rat, Mammal |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 beta [p Tyr279, p Tyr216] Antibody [NB100-81946]](https://resources.bio-techne.com/images/products/GSK-3-beta-[p-Tyr279--p-Tyr216]-Antibody-Western-Blot-NB100-81946-img0018.jpg "Western Blot: GSK-3 beta [p Tyr279, p Tyr216] Antibody [NB100-81946]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, CyTOF-ready, ICC, ICFlow |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Applications: | ELISA |
| Source: | Sf 9 (baculovirus) |
| Accession #: | NM_001145156 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #609739 |
| Applications: | WB, CyTOF-ready, ICC, ICFlow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1253C |
| Applications: | WB, Simple Western, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 beta Antibody [NBP1-31353]](https://resources.bio-techne.com/images/products/GSK-3-beta-Antibody-Western-Blot-NBP1-31353-img0015.jpg "Western Blot: GSK-3 beta Antibody [NBP1-31353]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #272536 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Rat IgG2b Monoclonal Clone #272535 |
| Applications: | ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #GT1619 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 beta Antibody (GT1619) [NBP3-13691]](https://resources.bio-techne.com/images/products/GSK-3-beta-Antibody-GT1619-Western-Blot-NBP3-13691-img0008.jpg "Western Blot: GSK-3 beta Antibody (GT1619) [NBP3-13691]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #272536 |
| Applications: | ICFlow |
Recombinant monoclonal antibody expressed in HEK293F cells
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #9G11 |
| Applications: | IHC, WB, ELISA, ICC/IF |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #SR1801 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #3D6B4 |
| Applications: | IHC, WB, ELISA, Flow, CyTOF-ready |
![Western Blot: GSK-3 beta Antibody (3D6B4)BSA Free [NBP2-52478]](https://resources.bio-techne.com/images/products/GSK-3-beta-Antibody-3D6B4-Western-Blot-NBP2-52478-img0004.jpg "Western Blot: GSK-3 beta Antibody (3D6B4)BSA Free [NBP2-52478]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2a Monoclonal Clone #272536 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #609739 |
| Applications: | ICFlow |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2A Monoclonal Clone #GT16711 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 beta Antibody (GT16711) [NBP3-13679]](https://resources.bio-techne.com/images/products/GSK-3-beta-Antibody-GT16711-Western-Blot-NBP3-13679-img0005.jpg "Western Blot: GSK-3 beta Antibody (GT16711) [NBP3-13679]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #272536 |
| Applications: | ICFlow |