Histone H1.1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33402

Novus Biologicals, part of Bio-Techne
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NBP2-33402
NBP2-33402-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Histone H1.1 Antibodies »

Product Summary for Histone H1.1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: SVETKPGASKVATKTKATGASKKLKKATGASKKSVKTPK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Histone H1.1 Antibody

Immunohistochemistry-Paraffin: Histone H1.1 Antibody [NBP2-33402]

Immunohistochemistry-Paraffin: Histone H1.1 Antibody [NBP2-33402]

Immunohistochemistry-Paraffin: Histone H1.1 Antibody [NBP2-33402] - Staining of human liver shows strong nuclear positivity in hepatocytes.

Applications for Histone H1.1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Histone H1.1

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. Histone H1.1 is a 215 amino acid long, 21 kDA protein encoded by the HIST1H1A gene. H1 proteins are essential in forming chromatin fiber and for the condensation of nucleosome chains into higher-order structured fibers. The HIST1H1A gene is active in apoptosis, PKA signaling, histone modification, and granzyme-A pathways. It interacts with genes CDK2, CDK7, CTCFL, DOT1L, and ADPRH. The HIST1H1A gene has been researched regarding measles, breast cancer, prostatitis, carcinoma, paratyphoid fever, and neuronitis.

Alternate Names

H1 histone family, member 1, H1.1, H1A, H1F1HIST1, histone 1, H1a, histone cluster 1, H1a, histone H1.1, MGC126642, MGC138345

Gene Symbol

H1-1

UniProt

Q02539 (Human)

Additional Histone H1.1 Products

Product Documents for Histone H1.1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Histone H1.1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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