Human Coagulation Factor XIV/Protein C Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB3349
Key Product Details
Species Reactivity
Human
Applications
Immunoprecipitation, Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 Clone # 390226
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Coagulation Factor XIV/Protein C
Ala43-Pro461
Accession # P04070
Ala43-Pro461
Accession # P04070
Specificity
Detects human Coagulation Factor XIV/Protein C in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Factor VII, rhFactor X, rhFactor XI, rhThrombin, rhUPA, rhHGFA, rhKallikrein 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15 is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for Human Coagulation Factor XIV/Protein C Antibody
Application
Recommended Usage
Immunoprecipitation
25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Human Coagulation Factor XIV/Protein C (Catalog # 3349-SE), see our available Western blot detection antibodies
Sample: Conditioned cell culture medium spiked with Recombinant Human Coagulation Factor XIV/Protein C (Catalog # 3349-SE), see our available Western blot detection antibodies
Western Blot
1 µg/mL
Sample: Recombinant Human Coagulation Factor XIV/Protein C (Catalog # 3349-SE)
Sample: Recombinant Human Coagulation Factor XIV/Protein C (Catalog # 3349-SE)
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Coagulation Factor XIV/Protein C
Coagulation factor XIV, also known as Protein C, has anti-coagulation activity by degrading factors VIIIa and Va, which are required for thrombin activation. Protein C deficiency results in hereditary thrombophilia, and a severe recessive form may result in massive thrombosis fatal to patient. The deduced amino acid sequence of human protein C predicts a signal peptide (aa 1‑32), a propeptide (aa 33‑42), and a mature chain (aa 43‑461), which can be converted into two disulfide-linked chains (light: aa 43‑199 and heavy: aa 200‑461). The amino acid sequence of human protein C is 99.8%, 80%, 70%, 69% and 54% identical to that of chimpanzee, canine, rat, mouse and chicken.
Long Name
Vitamin K-dependent Protein C
Alternate Names
Autoprothrombin IIA, PROC, Protein C
Gene Symbol
PROC
UniProt
Additional Coagulation Factor XIV/Protein C Products
Product Documents for Human Coagulation Factor XIV/Protein C Antibody
Product Specific Notices for Human Coagulation Factor XIV/Protein C Antibody
For research use only
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