Detects human Integrin alpha2b/CD41 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Integrin alpha5, alpha8, alphaV, beta3, beta5, beta6, recombinant mouse Integrin beta2b or beta3 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Scientific Data Images for Human Integrin alpha2b/CD41 APC-conjugated Antibody

Detection of Integrin alpha2b/CD41 in Human Blood Platelets by Flow Cytometry.

Human peripheral blood platelets were stained with FITC-conjugated Anti-Human Integrin a2b/CD41 Antibody (Clone P2) and either (A) Mouse Anti-Human Integrin a2b/CD41 APC-conjugated Monoclonal Antibody (Catalog # FAB7616A) or (B) Mouse IgG₁Allophycocyanin Isotype Control (Catalog # IC002A). FAB7616A stains the same population as Clone P2. View our protocol for Staining Membrane-associated Proteins.

Detection of Integrin alpha2b/CD41 in Human Platelets by Flow Cytometry

Human Platelets were stained with Mouse Anti-Human Integrin alpha2b/CD41 APC-conjugated Monoclonal Antibody (Catalog # FAB7616A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human Integrin alpha2b/CD41 APC-conjugated Antibody

Application

Recommended Usage

Flow Cytometry

10 µL/10⁶ cells
Sample: Human peripheral blood platelets

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: Integrin alpha 2b/CD41

Integrin alpha2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. Integrin alpha2b associates with Integrin beta3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. Integrin alpha2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, human Integrin alpha2b shares 80% and 78% amino acid sequence identity with mouse and rat Integrin alpha2b, respectively.

Alternate Names

CD41, GP2B, GPIIb, GTA, HPA3, ITGA2b

Entrez Gene IDs

3674 (Human); 16399 (Mouse); 29350 (Rat); 102119413 (Cynomolgus Monkey)

Gene Symbol

ITGA2B

Additional Integrin alpha 2b/CD41 Products

Product Documents for Human Integrin alpha2b/CD41 APC-conjugated Antibody

Product Datasheets

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COA

SDS

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Product Specific Notices for Human Integrin alpha2b/CD41 APC-conjugated Antibody

For research use only

Citations
Reviews

Spectra Viewer
Flow Cytometry

Human Integrin alpha2b/CD41 APC-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB7616A

Key Product Details

Species Reactivity

Validated:

Cited:

Applications