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Human Integrin  alpha4 beta1 (Research Grade Natalizumab Biosimilar) Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB10603

Recombinant Monoclonal Antibody For Research Use Only
R&D Systems, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG4 Clone # Hu114

Product Specifications

Immunogen

Human Integrin alpha4 beta1

Specificity

Detects human Integrin alpha4 beta1 in direct ELISAs. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Natalizumab. This product is for research use only.

Clonality

Monoclonal

Host

Human

Isotype

IgG4

Scientific Data Images

Detection of Integrin alpha4 beta1 in Human PBMC by Flow Cytometry.

Human PBMC were stained with (A) Human Anti-Human Integrin alpha4 beta1 (Research Grade Natalizumab Biosimilar) Monoclonal Antibody (Catalog # MAB10603) or (B) no primary antibody, followed by anti-Human IgG APC-conjugated Secondary Antibody (F0135) and Mouse anti-Human CD3 PE-conjugated Monoclonal Antibody (FAB100P). Cells were stained using our Staining Membrane-associated Proteins protocol.

Applications

Application
Recommended Usage

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

0.25 µg/106 cells
Sample: Human PBMC

Formulation, Preparation, and Storage

Purification

Protein A or G purified from cell culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Integrin alpha 4 beta 1

Natalizumab is a biosimilar directed against the extracellular domain of Human Integrin alpha4 beta1. It has been know to treat multiple sclerosis and Crohn's disease. Human Integrin alpha4 beta1 (Research Grade Natalizumab Biosimilar) Antibody is designd to be used in research use only.

Alternate Names

CD49d, IA4

Entrez Gene IDs

3676 (Human)

Gene Symbol

ITGA4

Additional Integrin alpha 4 beta 1 Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices

For research use only

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