Integrin alpha 4 beta 1 Products
Integrin alpha 4 beta 1, also known as VLA-4, is an Integrin family adhesion receptor that shares the beta 1 subunit with eleven other family members and the alpha 4 subunit with Integrin alpha 4 beta 7. The noncovalent heterodimer of alpha 4/CD49d and beta 1/CD29 subunits mediates cell adhesion to VCAM-1/CD106 on other cells and the CS-1 fragment of Fibronectin in the extracellular matrix.
Leukocytes (except for neutrophils), erythroid precursors, and some non-hematopoietic cells, such as epicardial, endothelial, and smooth muscle precursors, Schwann cells, and chorionic cells express a4b1. In the adult, a4b1 primarily regulates immune cell migration. Circulating leukocyte a4b1 is rapidly activated by inflamed endothelial cells that present VCAM-1 and chemokines such as CXCL12/SDF-1. This activation facilitates rolling, firm adhesion, and extravasation. During immune cell activation, a4b1 can function as a costimulatory molecule.
Products:
45 results for "Integrin alpha 4 beta 1" in Products
45 results for "Integrin alpha 4 beta 1" in Products
Integrin alpha 4 beta 1 Products
Integrin alpha 4 beta 1, also known as VLA-4, is an Integrin family adhesion receptor that shares the beta 1 subunit with eleven other family members and the alpha 4 subunit with Integrin alpha 4 beta 7. The noncovalent heterodimer of alpha 4/CD49d and beta 1/CD29 subunits mediates cell adhesion to VCAM-1/CD106 on other cells and the CS-1 fragment of Fibronectin in the extracellular matrix.
Leukocytes (except for neutrophils), erythroid precursors, and some non-hematopoietic cells, such as epicardial, endothelial, and smooth muscle precursors, Schwann cells, and chorionic cells express a4b1. In the adult, a4b1 primarily regulates immune cell migration. Circulating leukocyte a4b1 is rapidly activated by inflamed endothelial cells that present VCAM-1 and chemokines such as CXCL12/SDF-1. This activation facilitates rolling, firm adhesion, and extravasation. During immune cell activation, a4b1 can function as a costimulatory molecule.
Products:
| Source: | CHO |
| Accession #: | P13612 (Integrin alpha 4) & P05556 (Integrin beta 1) |
| Applications: | BA |
| Source: | CHO |
| Accession #: | AAH68313 (Integrin alpha 4) & P09055 (Integrin beta 1) |
| Applications: | BA |
Recombinant Monoclonal Antibody For Research Use Only
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Hu114 |
| Applications: | Flow, CyTOF-ready |
| Source: | CHO |
| Accession #: | XP_005573683.1 (Integrin alpha 4) & XP_005564991.1 |
| Applications: | BA |
| Assay Range: | 125 - 8,000 pg/mL |
| Applications: | ELISA |
Recombinant Monoclonal Antibody For Research Use Only
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Hu114 |
| Applications: | Flow, CyTOF-ready |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu114 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu114 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu114 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu114 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu114 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu114 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #Hu114 |
| Applications: | Flow |
Fluorescent ligand for α4β1 (VLA-4)
| Purity: | ≥90% |
Selective α4β1 (VLA-4) inhibitor
| Purity: | ≥95% |
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
| Chemical Name: | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
| Purity: | ≥98% |
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
| Chemical Name: | (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid |
| Purity: | ≥98% (HPLC) |
Red fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 646; fluorogenic; photostable
| Chemical Name: | 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-5-(((1-((3R,5S)-5-(((S)-1-carboxy-2-(4-((pyrrolidine-1-carbonyl)oxy)phenyl)ethyl)carbamoyl)-1-(phenylsulfonyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)benzoate |
| Purity: | ≥90% (HPLC) |
Yellow fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 549; fluorogenic; photostable
| Chemical Name: | 2-(3-(Azetidin-1-ium-1-ylidene)-6-(azetidin-1-yl)-3H-xanthen-9-yl)-4-(((1-((3R,5S)-5-(((S)-1-carboxy-2-(4-((pyrrolidine-1-carbonyl)oxy)phenyl)ethyl)carbamoyl)-1-(phenylsulfonyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)benzoate |
| Purity: | ≥85% (HPLC) |
α4β1 (VLA-4) antagonist
| Chemical Name: | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
| Purity: | ≥98% |
α4β1 (VLA-4) ligand
| Purity: | ≥95% (HPLC) |
Recombinant Monoclonal Antibody For Research Use Only
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Hu114 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Hu114 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Hu114 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal Clone #Hu114 |
| Applications: | Flow, CyTOF-ready |