Human LAP (TGF-beta 1) PE-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB2463P
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human, Mouse
Applications
Validated:
Flow Cytometry
Cited:
Flow Cytometry
Label
Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)
Antibody Source
Monoclonal Mouse IgG1 Clone # 27232
Product Specifications
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human LAP (TGF-beta 1)
Leu30-Arg278 (Cys33Ser)
Accession # P01137
Leu30-Arg278 (Cys33Ser)
Accession # P01137
Specificity
Detects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF‑ beta1, rhTGF‑ beta2, rhTGF‑ beta1.2, rhTGF‑ beta3, or rhTGF‑ alpha.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Scientific Data Images for Human LAP (TGF-beta 1) PE-conjugated Antibody
Detection of LAP (TGF-beta 1) in Human Platelets by Flow Cytometry.
Human CD41+platelets were stained with Mouse Anti-Human LAP (TGF-beta 1) PE-conjugated Monoclonal Antibody (Catalog # FAB2463P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Human LAP (TGF-beta 1) PE-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: Human CD41+ platelets
Sample: Human CD41+ platelets
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Background: LAP (TGF-beta 1)
The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta1, TGF‑ beta2, TGF‑ beta1.2, TGF‑ beta3, TGF‑ beta4, and TGF‑ beta5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.
Long Name
Latency-associated Peptide
Alternate Names
LAP (TGFbeta 1)
Entrez Gene IDs
7040 (Human)
Gene Symbol
TGFB1
UniProt
Additional LAP (TGF-beta 1) Products
Product Documents for Human LAP (TGF-beta 1) PE-conjugated Antibody
Product Specific Notices for Human LAP (TGF-beta 1) PE-conjugated Antibody
For research use only
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