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Human/Mouse DGK-iota Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB6435

R&D Systems, part of Bio-Techne
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MAB6435
MAB6435-SP

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Western Blot

Cited:

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 648538

Product Specifications

Immunogen

E. coli-derived recombinant human DGK‑ iota
Ser925-Val1065 (predicted)
Accession # O75912

Specificity

Detects human and mouse DGK‑ iota in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human DGK-alpha, -beta, -delta, -epsilon, -eta, -gamma, -kappa, -theta, or - zeta is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human/Mouse DGK-iota Antibody

Detection of Human and Mouse DGK-? antibody by Western Blot.

Detection of Human and Mouse DGK‑ iota by Western Blot.

Western blot shows lysates of SH-SY5Y human neuroblastoma cell line and mouse brain tissue. PVDF Membrane was probed with 1 µg/mL of Human/Mouse/Rat DGK-iota Antigen Affinity-purified Monoclonal Antibody (Catalog # MAB6435) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for DGK-iota at approximately 115 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Applications for Human/Mouse DGK-iota Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: SH‑SY5Y human neuroblastoma cell line and mouse brain tissue

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Sterile PBS to a final concentration of 0.5 mg/mL. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: DGK-iota

Diacylglycerol kinase iota (DGK-iota) is an approximately 110 kDa kinase that phosphorylates the lipid diacylglycerol. DGK-iota also inhibits RasGRP3 and limits Rap1 activation. It contains two zinc finger regions (aa 178-232 and aa 251-310), a catalytic domain (aa 372-507), and two ankyrin repeats (aa 958-990 and aa 997-1026). Over aa 925-1065, human DGK-iota shares 94% and 96% aa sequence identity with mouse and rat DGK-iota, respectively.

Long Name

Diacylglycerol Kinase, iota 64kDa

Alternate Names

DGKI, DGKiota

Entrez Gene IDs

9162 (Human); 320127 (Mouse); 688705 (Rat)

Gene Symbol

DGKI

UniProt

Additional DGK-iota Products

Product Documents for Human/Mouse DGK-iota Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human/Mouse DGK-iota Antibody

For research use only

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