Human XCR1 PE-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB8571P
Recombinant Monoclonal Antibody.
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human
Applications
Validated:
Flow Cytometry
Cited:
Flow Cytometry
Label
Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # 1097A
Product Specifications
Immunogen
E. coli-derived recombinant human XCR1
Met1-Thr31, Ser89-Lys103, His168-His190, Phe251-Tyr267
Accession # P46094
Met1-Thr31, Ser89-Lys103, His168-His190, Phe251-Tyr267
Accession # P46094
Specificity
Detects human XCR1 in direct ELISAs.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for Human XCR1 PE-conjugated Antibody
Detection of XCR1 in CD141+HLA-DR+Human Blood Monocytes by Flow Cytometry.
Human peripheral blood monocytes were stained with (A) Mouse Anti-Human HLA-DR Fluorescein-Conjugated Monoclonal Antibody (Catalog # FAB4869F), Mouse Anti-Human Thrombomodulin/BDCA-3 (CD141) APC-Conjugated Monoclonal Antibody (Catalog # FAB3947A) and (B) Rabbit Anti-Human XCR1 PE-conjugated Monoclonal Antibody (Catalog # FAB8571P, filled histogram) or isotype control antibody (Catalog # IC105P, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Human XCR1 PE-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: CD141+ HLA-DR+ human peripheral blood monocytes
Sample: CD141+ HLA-DR+ human peripheral blood monocytes
Reviewed Applications
Read 1 review rated 5 using FAB8571P in the following applications:
Formulation, Preparation, and Storage
Purification
Protein A or G purified from cell culture supernatant
Formulation
Supplied
in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: XCR1
XCR1, also known as GPR5 and Lymphotactin/SCM-1 (Single Cysteine Motif 1) Receptor, is a 38 kDa member of the G-protein coupled receptor 1 family. It binds XCL1/Lymphotactin/SCM-1 alpha and XCL2/SCM-1 beta. In addition, Human Herpes Virus 8 (HHV8) encodes two viral chemokines vCCL2/vMIP-II and vCCL3/vMIP-III that function as an antagonist and a highly selective agonist, respectively, for XCR1. XCR1 is expressed on neutrophils, CD8+ T cells, NK cells, CD4+ T cells and B cells. Human XCR1 is a 333 amino acid (aa), 7-transmembrane molecule. It contains a 32 aa N-terminus that lacks glycosylation sites and a 42 aa C-terminal cytoplasmic tail. Over the extracellular regions used for immunization, human XCR1 shares 62%, 54% and 64% aa identity with canine, mouse and porcine XCR1, respectively.
Long Name
Chemokine [C Motif] Receptor 1
Alternate Names
CCXCR1, GPR5
Gene Symbol
XCR1
UniProt
Additional XCR1 Products
Product Documents for Human XCR1 PE-conjugated Antibody
Product Specific Notices for Human XCR1 PE-conjugated Antibody
For research use only
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