IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44212

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL10252

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all IL-17/IL-17A Antibodies »

Product Specifications

Immunogen

This antibody was generated using a synthetic peptide of Q16552, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free

IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free Immunohistochemistry-Paraffin: IL-17/IL-17A Antibody [NBP3-44212]

Immunohistochemistry-Paraffin: IL-17/IL-17A Antibody [NBP3-44212]

Staining of human kidney shows no positivity in cells in tubules as expected.
IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free Immunohistochemistry-Paraffin: IL-17/IL-17A Antibody [NBP3-44212]

Immunohistochemistry-Paraffin: IL-17/IL-17A Antibody [NBP3-44212]

Staining of human rectum shows moderate cytoplasmic positivity in lymphoid cells.
IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free Immunohistochemistry-Paraffin: IL-17/IL-17A Antibody [NBP3-44212]

Immunohistochemistry-Paraffin: IL-17/IL-17A Antibody [NBP3-44212]

Staining of human lymph node shows moderate cytoplasmic positivity in a subset of lymphoid cells.
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Applications for IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS with Trehalose

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-17/IL-17A

Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by TCRalpha/beta+ CD4 CD8 thymocytes, as well as by activated CD4+ and CD4+ CD45RO+ memory T cells (1). IL-17 stimulates the expression of TNFalpha, IL-1 beta, IL-6, and IL-8 (2). In addition, IL-17 is involved in the induction of inducible nitric oxide synthase and cyclooxygenase 2 in chondrocytes (3). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis (4).

Long Name

Interleukin 17

Alternate Names

CTLA-8, CTLA8, IL-17A, IL17, IL17A

Gene Symbol

IL17A

Additional IL-17/IL-17A Products

Product Documents for IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-17/IL-17A Antibody (CL10252) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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