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Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03)

Novus Biologicals, part of Bio-Techne | Catalog # DDX1434P-100

Novus Biologicals, part of Bio-Techne
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DDX1434P-100-0.1mg

Key Product Details

Species Reactivity

Validated:

Human, Porcine

Cited:

Human, Porcine

Applications

Validated:

Binding Activity, Chromatin Immunoprecipitation (ChIP), Flow (Cell Surface), Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Cited:

Flow Cytometry, Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgA Clone # 111D9.03

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

rhua4b7 (R&D systems) and RPMI 8866 cells

Reactivity Notes

Use in Porcine reported in scientific literature (PMID:33809123).

Clonality

Monoclonal

Host

Mouse

Isotype

IgA

Theoretical MW

130 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03)

Immunocytochemistry/ Immunofluorescence: Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03) [DDX1434P-100]

Immunocytochemistry/ Immunofluorescence: Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03) [DDX1434P-100]

Immunocytochemistry/Immunofluorescence: Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03) [DDX1434P-100] - Gut sections (Crohn's disease).
Flow Cytometry: Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03) [DDX1434P-100]

Flow Cytometry: Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03) [DDX1434P-100]

Flow Cytometry: Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03) [DDX1434P-100] - FACS staining of RPMI 8866 cells (alpha4+beta7+) and HEK transfected cells with DDX1434(111D9) monoclonal antibody.

Applications for Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

Tris-NaCl pH 8

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin alpha 4 beta 7/LPAM-1

The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as integrin alpha4beta7, is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha4beta7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM-1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (1-4) The monoclonal antibody DATK32 recognizes a conformational epitope on the heterodimer. (1,2)

Alternate Names

CD49d/beta7, LPAM-1, LPAM1

Gene Symbol

ITGA4

Additional Integrin alpha 4 beta 7/LPAM-1 Products

Product Documents for Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Integrin alpha 4 beta 7/LPAM-1 Antibody (111D9.03)

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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