LAT Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27104

Novus Biologicals, part of Bio-Techne
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NBP2-27104
NBP2-27104SS
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Key Product Details

Species Reactivity

Human, Mouse, Primate

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all LAT Antibodies »

Product Specifications

Immunogen

A portion of amino acid 70-120 of human LAT was used as the immunogen. 86 cQPLGGSHRTPSSRRDS 101

Reactivity Notes

The amino acid sequence used as immunogen for the LAT antibody is 88% homologous in new world monkey, 82% homologous in rat, rabbit, canine and porcine.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for LAT Antibody

Western Blot: LAT Antibody [NBP2-27104]

Western Blot: LAT Antibody [NBP2-27104]

Western Blot: LAT Antibody [NBP2-27104] - analysis of LAT in mouse thymus tissue lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: LAT Antibody [NBP2-27104]

Immunohistochemistry-Paraffin: LAT Antibody [NBP2-27104]

Immunohistochemistry-Paraffin: LAT Antibody [NBP2-27104] - FFPE human small intestine stained with LAT antibody at 10 ug/mL.

Applications for LAT Antibody

Application
Recommended Usage

Western Blot

1 - 3 ug/mL

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LAT

Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their developmentThis protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads. These direct ligands then mediate the indirect interaction of LAT with proteins such as SLP-76, Vav1 and Itk. PLC-gamma 1, Vav1 and Itk contain pleckstrin homology (PH) domains that interact with the enzymatic product of phosphoinositide-3-kinase (PI3k).

Long Name

Linker for Activation of T cells

Alternate Names

pp36

Gene Symbol

LAT

Additional LAT Products

Product Documents for LAT Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for LAT Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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