Melanocortin-1 R/MC1R Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS1040

Novus Biologicals, part of Bio-Techne
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NLS1040
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Key Product Details

Species Reactivity

Validated:

Human, Monkey

Predicted:

Chimpanzee (100%), Orangutan (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all Melanocortin-1 R/MC1R Antibodies »

Product Specifications

Immunogen

Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human Melanocortin-1 R/MC1R.

Epitope

3rd cytoplasmic domain of human

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%).

Specificity

Human Melanocortin-1 R/MC1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Melanocortin-1 R/MC1R Antibody - BSA Free

Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody - BSA Free [NLS1040]

Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody - BSA Free [NLS1040]

Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody [NLS1040] - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody - BSA Free [NLS1040]

Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody - BSA Free [NLS1040]

Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody [NLS1040] - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Applications for Melanocortin-1 R/MC1R Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

2.5 - 5 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 5 using NLS1040 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Melanocortin-1 R/MC1R

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color. Pheomelanin generates free radicals in response to UV radiation, and elevated levels of pheomelanin have been associated with higher risk of UV-induced skin damage. Therefore, MC1R is a major determinant of sun sensitivity and genetic risk for melanoma and other skin cancers. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.

Long Name

Melanocortin 1 Receptor

Alternate Names

CMM5, MC1R, Melanocortin-1R, Melanocortin1R, MSH-R, Mshra, SHEP2, Tob

Entrez Gene IDs

4157 (Human)

Gene Symbol

MC1R

Additional Melanocortin-1 R/MC1R Products

Product Documents for Melanocortin-1 R/MC1R Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Melanocortin-1 R/MC1R Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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