mGluR5 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-02331

Novus Biologicals, part of Bio-Techne
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NBP1-02331
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bat, Bovine, Canine, Chicken, Equine, Hamster, Monkey, Primate, Rabbit

Predicted:

Avian (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all mGluR5 Antibodies »

Product Specifications

Immunogen

Synthetic 17 amino acid peptide from N-terminal extracellular domain of human mGluR5.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Zebra finch (100%), Platypus (100%), Lizard (100%), Opossum (88%), Pufferfish (88%), Zebrafish (82%).

Specificity

Human mGluR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for mGluR5 Antibody - BSA Free

Immunohistochemistry-Paraffin: mGluR5 Antibody - BSA Free [NBP1-02331]

Immunohistochemistry-Paraffin: mGluR5 Antibody - BSA Free [NBP1-02331]

Immunohistochemistry-Paraffin: mGluR5 Antibody - BSA Free [NBP1-02331] - Staining of human colon, myenteric plexus. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 6 ug/ml.

Applications for mGluR5 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

5.6 ug/ml

Immunohistochemistry-Paraffin

5.6 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: mGluR5

Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia. Summary of expresson: GRM5 has been reported to be expressed in various regions of the brain as well as in the spinal cord and dorsal root ganglia. ESTs have been isolated from human brain, eye, testis, and fetal libraries.Caution: GLUR5 refers to Ionotropic Glutamate Receptor 5, not to Metabotropic Glutamate Receptor 5 (mGLUR5).

Long Name

Metabotropic Glutamate Receptor 5

Alternate Names

GPRC1E, GRM5, mGlu5

Gene Symbol

GRM5

UniProt

P41594

Additional mGluR5 Products

Product Documents for mGluR5 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for mGluR5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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