Mouse TGF-beta  RII Antibody

Detection of Mouse TGF-beta RII by Western Blot

Differential Role of Cathepsins in UUO-Induced Kidney Fibrosis(A) Immunofluorescent staining of epithelial cell marker ZO-1 (green) with nuclei counterstained with DAPI (blue) in kidneys from sham WT or 14 days post-UUO WT, Ctsb−/−, Ctsl−/−, Ctss−/−, and Ctsk−/− mice and quantification of positive areas.(B) Immunoblot analysis of TGFBR1, TGFBR2, pSmad-2, and pSmad-3 and quantification relative to GAPDH in kidney extracts from sham WT or 14 days post-UUO WT, Ctsb−/−, and Ctsl−/− mice.(C) Immunoblot analysis of TGFBR1, TGFBR2, pSmad-2, and pSmad-3 and quantification relative to GAPDH in kidney extracts from sham WT or 14 days post-UUO WT, Ctss−/−, and Ctsk−/− mice.(D) Immunostaining of pSmad-2 and pSmad-3 in kidneys from the same sets of mice and quantification of positive areas.Scale in A: 100 μm. Scale in D: 50 μm. n = 8–10 per group. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31446224), licensed under a CC-BY license. Not internally tested by R&D Systems.