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TGF-beta RII Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

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107 results for "TGF-beta RII" in Products

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107 results for "TGF-beta RII" in Products

TGF-beta RII Products

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

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Applications: WB, Flow, IHC, CyTOF-ready, Neut
Reactivity: Human
Applications: WB
Reactivity: Mouse
Applications: WB, Flow, CyTOF-ready
Reactivity: Mouse
Applications: Flow
Reactivity: Human
Applications: Flow
Reactivity: Mouse
Applications: Flow
Reactivity: Human
Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: Flow
Reactivity: Mouse
Applications: WB, Flow
Reactivity: Mouse
Applications: Flow
Reactivity: Human
Applications: Flow
Reactivity: Human
Applications: Flow
Reactivity: Human
Applications: WB
Reactivity: Human
Applications: WB
Reactivity: Human
Applications: Flow
Reactivity: Mouse
Applications: Flow
Reactivity: Mouse
Applications: WB
Reactivity: Mouse
Applications: BA
Applications: ELISA
Reactivity: Human
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