NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-47966MFV610

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP2-44876

Alexa Fluor 350

NBP2-47966AF350

Alexa Fluor 405

NBP2-47966AF405

Alexa Fluor 488

NBP2-47966AF488

Alexa Fluor 532

NBP2-47966AF532

Alexa Fluor 594

NBP2-47966AF594

Alexa Fluor 647

NBP2-47966AF647

Alexa Fluor 700

NBP2-47966AF700

Alexa Fluor 750

NBP2-47966AF750

Allophycocyanin

NBP2-47966APC

Allophycocyanin/Cy7

NBP2-47966APCCY7

Biotin

NBP2-47966B

CoraFluor 1

NBP2-47966CL1

DyLight 350

NBP2-47966UV

DyLight 405

NBP2-47966V

DyLight 488

NBP2-47966G

DyLight 550

NBP2-47966R

DyLight 594

NBP2-47966DL594

DyLight 650

NBP2-47966C

DyLight 680

NBP2-47966FR

DyLight 755

NBP2-47966IR

FITC

NBP2-47966F

HRP

NBP2-47966H

Janelia Fluor 525

NBP2-47966JF525

Janelia Fluor 549

NBP2-47966JF549

Janelia Fluor 585

NBP2-47966JF585

Janelia Fluor 635

NBP2-47966JF635

Janelia Fluor 646

NBP2-47966JF646

Janelia Fluor 669

NBP2-47966JF669

mFluor Violet 450 SE

NBP2-47966MFV450

mFluor Violet 500 SE

NBP2-47966MFV500

PE

NBP2-47966PE

PE/Atto594

NBP2-47966PEATT594

PE/Cy5.5

NBP2-47966PECY55

PE/Cy7

NBP2-47966PECY7

PerCP

NBP2-47966PCP

Forumulation

Catalog #

Azide and BSA Free

NBP2-47966

IHC-Prediluted

NBP2-48297

Product Summary
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse (Negative), Primate, Rat (Negative)

Applications

CyTOF-ready, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

mFluor Violet 610 SE (Excitation = 421 nm, Emission = 613 nm)

Antibody Source

Monoclonal Mouse IgG₁ kappa Clone # NTR/912

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all NGFR/TNFRSF16 Antibodies »

Product Summary for NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE]

Immunogen

Recombinant human NGFR/TNFRSF16/p75NTR protein (Uniprot: P08138)

Reactivity Notes

Non-Human primates. Does not react with Mouse or Rat.

Localization

Cell surface and cytoplasmic

Specificity

It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

Marker

Soft Tissue Tumor Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Scientific Data Images for NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE]

NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE] [NBP2-47966MFV610] -

NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE] [NBP2-47966MFV610] - Vial of mFluor Violet 610 conjugated antibody. mFluor Violet 610 is optimally excited at 421 nm by the Violet laser (405 nm) and has an emission maximum of 613 nm.

Applications for NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE]

Application

Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: NGFR/TNFRSF16

p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.

Long Name

Nerve Growth Factor Receptor

Alternate Names

CD271, NGF R, p75 NTR, TNFRSF16

Gene Symbol

NGFR

Additional NGFR/TNFRSF16 Products

Product Documents for NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE]

Product Datasheets

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COA

SDS

Product Specific Notices for NGFR/TNFRSF16/p75NTR Antibody (NTR/912) [mFluor Violet 610 SE]

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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