PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These proteins play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Long Name

Paired Box Gene 3 [Waardenburg Syndrome 1]

Alternate Names

HUP2, WS1

Gene Symbol

PAX3

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Product Documents for Pax3 Antibody (PAX3/8426) [Janelia Fluor® 635]

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Product Specific Notices for Pax3 Antibody (PAX3/8426) [Janelia Fluor® 635]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Pax3 Antibody (PAX3/8426) [Janelia Fluor® 635]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20757JF635

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Applications for Pax3 Antibody (PAX3/8426) [Janelia Fluor® 635]

Immunohistochemistry-Paraffin

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Background: Pax3