PIF1 Antibody [DyLight 550]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-97931R

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Mouse

Applications

ICC/IF (Negative), Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot (Negative)

Label

DyLight 550 (Excitation = 562 nm, Emission = 576 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PIF1 Antibodies »

Product Summary for PIF1 Antibody [DyLight 550]

Immunogen

A synthetic peptide made to an internal portion of the human PIF1 protein (between residues 400-500) [UniProt Q9H611]

Localization

Nucleus.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for PIF1 Antibody [DyLight 550]

Application
Recommended Usage

Immunohistochemistry

1:300

Immunohistochemistry-Paraffin

1:300
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PIF1

PIF1 (pre-implantation factor, PIF1 5'-to-3' DNA helicase homolog, PIF, PIF1/RRM3 DNA helicase-like protein, C15orf20) is a member of the helicase family associated with embryo association with the uterus. PIF1 is also a DNA dependent ATPase that negatively regulates telomerase, the reverse transcriptase that affects telomere length (PMID 16522649). PIF1 is expressed in the nucleus in the late S/G2 phase and is carefully regulated by the cell cycle. In human tumor cells, the deletion of the PIF1 gene reduces the survival of both the p53-deficient and p53-proficient cells by initiating apoptosis by blocking S-phase entry and progression (PMID 21616935). Acting as a G4 resolvase, PIF1 prevents the formation of G4 (G-quadruplex) structures by stabilizing DNA sequences (PMID 20524933).

Alternate Names

C15orf20, PIF, PIF1 5-to-3 Prime DNA helicase homolog, RRM3 DNA helicase-like protein

Gene Symbol

PIF1

Additional PIF1 Products

Product Documents for PIF1 Antibody [DyLight 550]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PIF1 Antibody [DyLight 550]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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