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SHP-1 Antibody (PTPN6/7543) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26999B

Novus Biologicals, part of Bio-Techne
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NBP3-26999B

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Biotin

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # PTPN6/7543

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Recombinant fragment (around aa395-595) of human SHP-1 protein (exact sequence is proprietary)

Localization

Cytoplasm, Nucleus, In neurons, translocates into the nucleus after treatment with angiotensin II,

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for SHP-1 Antibody (PTPN6/7543) [Biotin]

Application
Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHP-1

The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.

Long Name

Src Homology Region 2 Domain Phosphatase 1

Alternate Names

HCPH, PTP1C, PTPN6, SHP1

Gene Symbol

PTPN6

Additional SHP-1 Products

Product Documents for SHP-1 Antibody (PTPN6/7543) [Biotin]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for SHP-1 Antibody (PTPN6/7543) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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