SHP-1 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
119 results for "SHP-1" in Products
119 results for "SHP-1" in Products
SHP-1 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #255402 |
| Applications: | ICC |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR41-02 |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: SHP-1 Antibody (SR41-02) [NBP2-67321]](https://resources.bio-techne.com/images/products/SHP-1-Antibody-SR41-02-Western-Blot-NBP2-67321-img0010.jpg "Western Blot: SHP-1 Antibody (SR41-02) [NBP2-67321]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Western Blot: SHP-1 Antibody [NBP1-32179]](https://resources.bio-techne.com/images/products/PTPN6-Antibody-Western-Blot-NBP1-32179-img0003.jpg "Western Blot: SHP-1 Antibody [NBP1-32179]")
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: SHP-1 Antibody [NBP1-83276]](https://resources.bio-techne.com/images/products/PTPN6-Antibody-Western-Blot-NBP1-83276-img0006.jpg "Western Blot: SHP-1 Antibody [NBP1-83276]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #7I1K3 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: SHP-1 Antibody (7I1K3) [NBP3-15669]](https://resources.bio-techne.com/images/products/SHP-1-Antibody-7I1K3-Western-Blot-NBP3-15669-img0006.jpg "Western Blot: SHP-1 Antibody (7I1K3) [NBP3-15669]")
| Source: | E. coli |
| Accession #: | P29350 |
| Applications: | EnzAct |
Protein tyrosine phosphatase inhibitor
| Chemical Name: | Trisodium vanadate |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, ELISA |
![Western Blot: SHP-1 Antibody [NB100-58968]](https://resources.bio-techne.com/images/products/SHP-1-Antibody-Western-Blot-NB100-58968-img0005.jpg "Western Blot: SHP-1 Antibody [NB100-58968]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![SHP-1 [p Tyr536] Antibody](https://resources.bio-techne.com/images/products/nbp3-23398_rabbit-shp-1-p-tyr536-pab-19920231915410.jpg "Western Blot: SHP-1 [p Tyr536] Antibody [NBP3-23398] -")
Non-competitive protein tyrosine phosphatase inhibitor
| Chemical Name: | 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #M160 |
| Applications: | WB, ICC/IF, IP |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #S06-4C8 |
| Applications: | IHC, WB |
![Western Blot: SHP-1 Antibody (S06-4C8) [NBP3-19611]](https://resources.bio-techne.com/images/products/SHP-1-Antibody-S06-4C8-Western-Blot-NBP3-19611-img0002.jpg "Western Blot: SHP-1 Antibody (S06-4C8) [NBP3-19611]")
Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![SHP-1 [p Ser591] Antibody](https://resources.bio-techne.com/images/products/nbp3-23399_rabbit-shp-1-p-ser591-pab-19920231911473.jpg "Western Blot: SHP-1 [p Ser591] Antibody [NBP3-23399] -")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: SHP-1 Antibody [NB100-60553]](https://resources.bio-techne.com/images/products/PTPN6-Antibody-Western-Blot-NB100-60553-img0002.jpg "Western Blot: SHP-1 Antibody [NB100-60553]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #PTPN6/7543 |
| Applications: | IHC |
| Applications: | WB |
![Western Blot: SHP-1 Overexpression Lysate [NBP2-05773]](https://resources.bio-techne.com/images/products/PTPN6-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-05773-img0001.jpg "Western Blot: SHP-1 Overexpression Lysate [NBP2-05773]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #CPTC-PTPN6-2 |
| Applications: | WB, ELISA |
| Applications: | WB |
![Western Blot: SHP-1 Overexpression Lysate [NBL1-14976]](https://resources.bio-techne.com/images/products/PTPN6-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-14976-img0002.jpg "Western Blot: SHP-1 Overexpression Lysate [NBL1-14976]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #PTPN6/7544 |
| Applications: | IHC |
| Applications: | ELISA |
| Applications: | ELISA |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |