SHP-2/PTPN11 Antibody (S08-3G2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19502

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19502-100ul
NBP3-19502-50ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S08-3G2

Concentration

0.3 mg/ml

View all SHP-2 Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human SHP-2/PTPN11 (Uniprot # Q06124)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

68 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SHP-2/PTPN11 Antibody (S08-3G2)

Western Blot: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502]

Western Blot: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502]

Western Blot: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502] - Western blot detection of SHP-2/PTPN11 in Hela, 293 cell lysates using NBP3-19502 (1:1000 diluted). Predicted band size: 68kDa. Observed band size: 68kDa.
Immunohistochemistry-Paraffin: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502]

Immunohistochemistry-Paraffin: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502]

Immunohistochemistry-Paraffin: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502] - Immunohistochemistry of SHP-2/PTPN11 in paraffin-embedded Human breast cancer tissue using NBP3-19502 at dilution 1/50

Applications for SHP-2/PTPN11 Antibody (S08-3G2)

Application
Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SHP-2

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Long Name

Src Homology Region 2 Domain Phosphatase 2

Alternate Names

PTP1D, PTP2C, PTPN11, SH-PTP2, SHP2

Gene Symbol

PTPN11

Additional SHP-2 Products

Product Documents for SHP-2/PTPN11 Antibody (S08-3G2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SHP-2/PTPN11 Antibody (S08-3G2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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