SHP-2/PTPN11 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00005781-B02P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Proximity Ligation Assay, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SHP-2 Antibodies »

Product Specifications

Immunogen

PTPN11 (AAH08692.1, 1 a.a. - 460 a.a.) full-length human protein. MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCR

Specificity

PTPN11 - protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1),

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Description

Quality control test: Antibody reactive against mammalian transfected lysate.

Scientific Data Images for SHP-2/PTPN11 Antibody

Western Blot: SHP-2/PTPN11 Antibody [H00005781-B02P]

Western Blot: SHP-2/PTPN11 Antibody [H00005781-B02P]

Western Blot: SHP-2/PTPN11 Antibody [H00005781-B02P] - Analysis of PTPN11 expression in transfected 293T cell line by PTPN11 polyclonal antibody. Lane 1: PTPN11 transfected lysate(50.6 KDa). Lane 2: Non-transfected lysate.
Proximity Ligation Assay: SHP-2/PTPN11 Antibody [H00005781-B02P]

Proximity Ligation Assay: SHP-2/PTPN11 Antibody [H00005781-B02P]

Proximity Ligation Assay: SHP-2/PTPN11 Antibody [H00005781-B02P] - Analysis of protein-protein interactions between FLT1 and PTPN11. Huh7 cells were stained with anti-FLT1 rabbit purified polyclonal 1:600 and anti-PTPN11 mouse purified polyclonal antibody 1:100. Each red dot represents the detection of protein-protein in
Proximity Ligation Assay: SHP-2/PTPN11 Antibody [H00005781-B02P]

Proximity Ligation Assay: SHP-2/PTPN11 Antibody [H00005781-B02P]

Proximity Ligation Assay: SHP-2/PTPN11 Antibody [H00005781-B02P] - Analysis of protein-protein interactions between CRKL and PTPN11. Mahlavu cells were stained with anti-CRKL rabbit purified polyclonal 1:600 and anti-PTPN11 mouse purified polyclonal antibody 1:100. Each red dot represents the detection of protein-protein

Applications for SHP-2/PTPN11 Antibody

Application
Recommended Usage

Proximity Ligation Assay

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: SHP-2

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]

Long Name

Src Homology Region 2 Domain Phosphatase 2

Alternate Names

PTP1D, PTP2C, PTPN11, SH-PTP2, SHP2

Entrez Gene IDs

5781 (Human)

Gene Symbol

PTPN11

UniProt

AAH08692.1 (Human)

Additional SHP-2 Products

Product Documents for SHP-2/PTPN11 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SHP-2/PTPN11 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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