Smad4 Antibody (SMAD/6309R) [DyLight 350]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14116UV

Submit a review

Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP3-13963

Alexa Fluor 350

NBP3-14116AF350

Alexa Fluor 405

NBP3-14116AF405

Alexa Fluor 488

NBP3-14116AF488

Alexa Fluor 532

NBP3-14116AF532

Alexa Fluor 594

NBP3-14116AF594

Alexa Fluor 647

NBP3-14116AF647

Alexa Fluor 700

NBP3-14116AF700

Alexa Fluor 750

NBP3-14116AF750

Allophycocyanin

NBP3-14116APC

Biotin

NBP3-14116B

CoraFluor 1

NBP3-14116CL1

DyLight 405

NBP3-14116V

DyLight 488

NBP3-14116G

DyLight 550

NBP3-14116R

DyLight 594

NBP3-14116DL594

DyLight 650

NBP3-14116C

DyLight 680

NBP3-14116FR

DyLight 755

NBP3-14116IR

FITC

NBP3-14116F

HRP

NBP3-14116H

Janelia Fluor 525

NBP3-14116JF525

Janelia Fluor 549

NBP3-14116JF549

Janelia Fluor 585

NBP3-14116JF585

Janelia Fluor 635

NBP3-14116JF635

Janelia Fluor 646

NBP3-14116JF646

Janelia Fluor 669

NBP3-14116JF669

PE

NBP3-14116PE

PerCP

NBP3-14116PCP

Forumulation

Catalog #

Azide and BSA Free

NBP3-14116

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry-Paraffin

Label

DyLight 350 (Excitation = 353 nm, Emission = 432 nm)

Antibody Source

Monoclonal Rabbit IgG Kappa Clone # SMAD/6309R

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Smad4 Antibodies »

Product Specifications

Immunogen

Recombinant human full-length (aa1-552) Smad4 protein (Uniprot: Q13485 )

Reactivity Notes

0

Localization

Nucleus, Cytoplasm, Cytoplasmic in absence of ligand, Migrates to nucleus when complexed with R-SMAD

Marker

Pancreatic Adenocarcinoma Marker / Tumor Suppressor

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for Smad4 Antibody (SMAD/6309R) [DyLight 350]

Application

Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Smad4

Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFbeta/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFbeta and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFbeta signaling by interfering with TGFbeta-mediated phosphorylation of other Smad family members.

Long Name

Mothers Against DPP Homolog 4

Alternate Names

DPC4, MADH4

Gene Symbol

SMAD4

Additional Smad4 Products

Product Documents for Smad4 Antibody (SMAD/6309R) [DyLight 350]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Smad4 Antibody (SMAD/6309R) [DyLight 350]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews