Stat5 is part of a 7 protein family known as signal transducer and activator of transcription (STAT) which contributes to signal transduction by cytokine, hormone and growth factor (1). Signal transducer and activator of transcription 5 (Stat5) functions both in signal transduction and activation of transcription. It has been found that cytoplasmic Stat5 is translocated to the nucleus in response to phosphorylation. Stat5 225; tyrosine phosphorylation is activated predominantly by IL2 but also by IL-3, IL-5, IL-7, IL-9, IL-15, G-CSF andGM-CSF(2). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. NCoA-1/SRC-1 acts as a coactivator for both the alpha- and beta-isoforms of Stat5 (3).

Long Name

Signal Transducer and Activator of Transcription 5

Alternate Names

MGF, signal transducer and activator of transcription 5A, STAT5

Gene Symbol

STAT5A

Additional STAT5a Products

Product Documents for STAT5A Antibody (251610) [HRP]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for STAT5A Antibody (251610) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

Spectra Viewer
Flow Cytometry

STAT5A Antibody (251610) [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # FAB21741H

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all STAT5a Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications for STAT5A Antibody (251610) [HRP]

CyTOF-ready

Immunocytochemistry

Intracellular Staining by Flow Cytometry

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: STAT5a